| First Author | Veugelen S | Year | 2016 |
| Journal | Neuron | Volume | 90 |
| Issue | 2 | Pages | 410-6 |
| PubMed ID | 27100199 | Mgi Jnum | J:239478 |
| Mgi Id | MGI:5828968 | Doi | 10.1016/j.neuron.2016.03.010 |
| Citation | Veugelen S, et al. (2016) Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Abeta Peptide Seeds. Neuron 90(2):410-6 |
| abstractText | Recently it was proposed that the familial Alzheimer's disease (FAD) causing presenilin (PSEN) mutations PSEN1-L435F and PSEN1-C410Y do not support the generation of Abeta-peptides from the amyloid precursor protein (APP). This challenges the amyloid hypothesis and disagrees with previous work showing that PSEN1 FAD causing mutations generate invariably long Abeta and seed amyloid. We contrast here the proteolytic activities of these mutant PSEN alleles with the complete loss-of-function PSEN1-D257A allele. We find residual carboxy- and endo-peptidase gamma-secretase activities, similar to the formerly characterized PSEN1-R278I. We conclude that the PSEN1-L435F and -C410Y mutations are extreme examples of the previously proposed "dysfunction" of gamma-secretase that characterizes FAD-associated PSEN. This Matters Arising paper is in response to Xia et al. (2015), published in Neuron. See also the response by Xia et al. (2016), published in this issue. |
