| First Author | Fredriksson JM | Year | 2005 |
| Journal | FEBS Lett | Volume | 579 |
| Issue | 25 | Pages | 5680-4 |
| PubMed ID | 16219308 | Mgi Jnum | J:102385 |
| Mgi Id | MGI:3607435 | Doi | 10.1016/j.febslet.2005.09.044 |
| Citation | Fredriksson JM, et al. (2005) Cold-induced expression of the VEGF gene in brown adipose tissue is independent of thermogenic oxygen consumption. FEBS Lett 579(25):5680-4 |
| abstractText | To examine whether cold-induced vascular endothelial growth factor (VEGF) gene expression in brown adipose tissue involved generation of hypoxic oxygen levels by thermogenic processes, we cold-exposed wild-type mice, as well as uncoupling protein-1 (UCP1)-ablated mice in which no thermogenesis in brown adipocytes can be induced. Cold exposure stimulated VEGF expression in both wild-type and UCP1-ablated mice. Unexpectedly, the effect was 3-fold higher in UCP1-ablated animals, whereas cultured brown adipocytes from both genotypes responded identically to norepinephrine stimulation. These results demonstrate that generation of low oxygen levels does not contribute to cold-induced VEGF expression in brown adipose tissue, but the results are consistent with an adrenergic regulation of expression. |
