| First Author | Togashi H | Year | 2011 |
| Journal | Science | Volume | 333 |
| Issue | 6046 | Pages | 1144-7 |
| PubMed ID | 21798896 | Mgi Jnum | J:175242 |
| Mgi Id | MGI:5285022 | Doi | 10.1126/science.1208467 |
| Citation | Togashi H, et al. (2011) Nectins establish a checkerboard-like cellular pattern in the auditory epithelium. Science 333(6046):1144-7 |
| abstractText | In the auditory epithelium of the cochlea, the sensory hair cells and supporting cells are arranged in a checkerboard-like fashion, but the mechanism underlying this cellular patterning is unclear. We found that mouse hair cells and supporting cells express the immunoglobulin-like adhesion molecules nectin-1 and -3, respectively, and that their interaction mediates the heterotypic adhesion between these two cell types. Genetic removal of nectin-1 or -3 disrupted the checkerboard-like pattern, inducing aberrant attachment between hair cells. When cells expressing either nectin-1 or -3 were cocultured, they arranged themselves into a mosaic pattern. Thus, nectin-1 and -3 promote the formation of the checkerboard-like pattern of the auditory epithelia. |
