| Type | MGI:General | Description | mutant bone marrow macrophages (BMMs) isolated from 6- to 8-wk-old mice and cultured with M-CSF and RANKL for 3-5 days display enhanced osteoclast differentiation relative to wild-type controls increased osteoclastogenesis is also noted in the co-culture system with either wild-type or mutant bone marrow stromal cells following addition of TNF or LPS, in vitro osteoclast differentiation is significantly increased, as quantified by the number of TRAP+ osteoclasts |
