| First Author | Lu W | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 5 | Pages | 643-50 |
| PubMed ID | 18242177 | Mgi Jnum | J:131847 |
| Mgi Id | MGI:3774715 | Doi | 10.1016/j.febslet.2008.01.035 |
| Citation | Lu W, et al. (2008) R-spondin1 synergizes with Wnt3A in inducing osteoblast differentiation and osteoprotegerin expression. FEBS Lett 582(5):643-50 |
| abstractText | R-spondins are a new group of Wnt/beta-catenin signaling agonists, however, the role of these proteins in bone remains unclear. We reported herein that R-sponin1 (Rspo1) acted synergistically with Wnt3A to activate Wnt/beta-catenin signaling in the uncommitted mesenchymal C2C12 cells. Furthermore, we found that Rspo1 at concentrations as low as 10ng/ml synergized strongly with Wnt3A to induce C2C12 osteoblastic differentiation and osteoprotegerin expression. These events were blocked by Wnt/beta-catenin signaling antagonist Dickkopf-1. Finally, we demonstrated that Rspo1 synergized with Wnt3A to induce primary mouse osteoblast differentiation. Together, these findings suggest that Rpos1 may play an important role in bone remodeling. |
