| Primary Identifier | IPR034782 | Type | Family |
| Short Name | SAFB2 |
| description | SAFB2 belongs to the scaffold attachment factor B (SAFB) family. It shares protein sequence similarity with SAFB1. Like SAFB1, it also has functions in transcriptional repression and RNA splicing []. Both SAFB1 and SAFB2 play an important role in cancer, particularly in breast tumorigenesis []. Nevertheless, SAFB2 seems to have non-redundant functions in mouse male reproductive tract compared to SAFB1 [].Scaffold attachment factor B (SAFB) family members include SAFB1, SAFB2 and SAFB-like transcriptional modulator, SLTM. They contain an N-terminal DNA-binding (SAF-A/B, Acinus and PIAS, SAP) domain, an RNA-binding domain (RBD) and an C-terminal arginine/glycine motif RGG/RG domain. Their RGG/RG domain, which partially overlaps with a putative coiled-coil domain, is most conserved and is likely to be involved in protein-protein interactions []. |
