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Protein Coding Gene : Dhh desert hedgehog

Primary Identifier  MGI:94891 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  13363
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables patched binding activity. Involved in several processes, including Schwann cell development; male gonad development; and paracrine signaling. Acts upstream of or within several processes, including Leydig cell differentiation; male sex determination; and osteoblast differentiation. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; heart and pericardium; and yolk sac. Used to study 46,XY sex reversal. Human ortholog(s) of this gene implicated in 46,XY sex reversal and 46,XY sex reversal 7. Orthologous to human DHH (desert hedgehog signaling molecule).
PHENOTYPE: Homozygous null mutants are male sterile, failing to produce mature spermatozoa; peripheral nerves are abnormal, with thin and disorganized perineurial sheaths. High penetrance of pseudohermaphroditism observed on some mixed backgrounds. [provided by MGI curators]
  • synonyms:
  • MGI:2146288,
  • expressed sequence C78960,
  • Dhh,
  • MGD-MRK-8842,
  • C78960,
  • desert hedgehog

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

7 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

2 Driver For