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Protein Coding Gene : Erbb4 erb-b2 receptor tyrosine kinase 4

Primary Identifier  MGI:104771 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  13869
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables GABA receptor binding activity; epidermal growth factor receptor activity; and neuregulin receptor activity. Involved in several processes, including cell surface receptor signaling pathway; mammary gland development; and nervous system development. Acts upstream of or within several processes, including cellular response to epidermal growth factor stimulus; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of protein localization to cell surface. Is active in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including brain; embryo ectoderm; facial prominence; heart; and mammary gland primordium. Used to study schizophrenia. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4).
PHENOTYPE: Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects. [provided by MGI curators]
  • synonyms:
  • Erbb4,
  • MGD-MRK-28062,
  • ErbB4,
  • Her4,
  • erb-b2 receptor tyrosine kinase 4

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

26 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

1 Driver For