| Primary Identifier | MGI:2136940 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 59004 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including SUMO ligase activity; transcription corepressor activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of keratinocyte apoptotic process; and protein sumoylation. Acts upstream of or within central nervous system development; regulation of signal transduction; and skin epidermis development. Located in nuclear matrix and nucleoplasm. Part of transferase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hair follicle; and heart. Orthologous to human PIAS4 (protein inhibitor of activated STAT 4). PHENOTYPE: Homozygous null mutants display mild postnatal lethality or a normal phenotype depending on strain background. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
