| First Author | Buus TB | Year | 2016 |
| Journal | Eur J Immunol | Volume | 46 |
| Issue | 10 | Pages | 2363-2375 |
| PubMed ID | 27418188 | Mgi Jnum | J:249502 |
| Mgi Id | MGI:5923523 | Doi | 10.1002/eji.201646407 |
| Citation | Buus TB, et al. (2016) The major diversification of Vgamma1.1+ and Vgamma2+ thymocytes in mice occurs after commitment to the gammadelta T-cell lineage. Eur J Immunol 46(10):2363-2375 |
| abstractText | gammadelta T cells are a heterogeneous cell population with different subsets playing specialized and often opposing roles during immune responses. A key question is whether gammadelta thymocytes are determined for their effector function already at an early stage, before their commitment to the gammadelta T-cell lineage, or are instructed during their later development. Here, we show that the adult Vgamma1.1+ and Vgamma2+ gammadelta T-cell subsets both go through a CD73+ CD24+ development stage, and that the gene regulation involved in lineage commitment is shared by both subsets. We demonstrate that the major subset diversification first occurs after the cells have committed to the gammadelta T-cell lineage, strongly supporting an instructive model for functional programming of gammadelta T cells. In conclusion, we show that the two major adult gammadelta T-cell subsets in mice develop through a shared pathway utilizing similar cellular machinery and that they diverge after the CD24+ CD73+ maturity stage. |
