| Primary Identifier | IPR034744 | Type | Domain |
| Short Name | RH2 |
| description | The RH2 (RILP homology 2) Rab-binding domain is found in the following animalproteins [, , ]:Rab interacting lysosomal proteins (RILP), which interacts with Rab7,Rab34, and Rab36.RILP-like 1 (RILP-L1), which interacts with Rab12, Rab34, and Rab36.RILP-like 2 (RILP-L2), which interacts with Rab34 and Rab36.JNK-interacting protein 3 (JIP3), which interacts with Rab36 alone.JNK-interacting protein 4 (JIP4), which interacts with Rab36 alone.The RH2 domain is folded into a long helix alpha1 and a short helix alpha2connected by a very tight loop. The RH2 domain forms atightly associated four helices homodimer in which both helices alpha1 andalpha2 are involved in dimerization. Such a homodimer binds to two separateRab-GTP molecules on opposite sides, with both helices involved in theinteraction with Rab. In the complex interface, although each Rab-GTPinteracts with both helices of the RH2 domain, these two helices arecontributed by two different molecules, with helix alpha1 coming from oneprotomer and helix alpha2 from the other protomer [].The entry represents the entire RH2 domain. |
