| Type | MGI:General | Description | at E10.5, embryos exhibit an increase in the proportion of gamma-H2AX-positive cells; DNA damage is detected in all embryonic tissues but is particularly evident in embryonic brain a high number of p53 positive cells is observed throughout the embryo at E10.5 and onward, indicating extensive p53 activation MEFs obtained from E11.5 and E12.5 embryos show phenotypes associated with genome instability, including increased levels of 53BP1 nuclear foci, micronucleus formation and polyploidy |
