| First Author | Osugi T | Year | 1996 |
| Journal | FEBS Lett | Volume | 391 |
| Issue | 1-2 | Pages | 11-6 |
| PubMed ID | 8706895 | Mgi Jnum | J:35303 |
| Mgi Id | MGI:82753 | Doi | 10.1016/0014-5793(96)00696-5 |
| Citation | Osugi T, et al. (1996) Involvement of a single-stranded DNA binding protein, ssCRE-BP/Pur alpha, in morphine dependence. FEBS Lett 391(1-2):11-6 |
| abstractText | We have purified a nuclear protein from mouse cerebella that binds to single-stranded oligo-DNA of cAMP response element and is modulated by morphine treatment. Isolation of the cDNA clone showed that the nuclear protein (ssCRE-BP) was identical to Pur alpha, a DNA binding protein for single-stranded purine-rich sequences that was originally isolated as a replication factor. ssCRE-BP/Pur alpha and mRNA were abundant in the brain. The levels of ssCRE-BP/Pur alpha and the transcript were not changed by chronic morphine treatment, however, the levels of an activator of ssCRE-BP/Pur alpha, which is necessary for the DNA binding, may be modulated by the treatment. |
