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Protein Coding Gene : Degs2 delta 4-desaturase, sphingolipid 2
Primary Identifier  MGI:1917309 Organism  mouse, laboratory
Chromosome  12 NCBI Gene Number  70059
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables sphingolipid delta-4 desaturase activity. Acts upstream of or within sphinganine metabolic process and sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Is expressed in stomach. Orthologous to human DEGS2 (delta 4-desaturase, sphingolipid 2).
PHENOTYPE: Mice homozygous for a null allele exhibit normal skin barrier function but altered phytosphingosine ceramides with a bias toward very-long-fatty acid PHS-CER rather than long-chain ones. [provided by MGI curators]
  • synonyms:
  • Des2,
  • RIKEN cDNA 2210008A03 gene,
  • 2210008A03Rik,
  • Degs2,
  • AI852933,
  • MGI:2144905,
  • expressed sequence AI852933,
  • delta 4-desaturase, sphingolipid 2
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