| First Author | Wakabayashi Y | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 6 | Pages | 533-9 |
| PubMed ID | 12717433 | Mgi Jnum | J:83651 |
| Mgi Id | MGI:2662810 | Doi | 10.1038/ni927 |
| Citation | Wakabayashi Y, et al. (2003) Bcl11b is required for differentiation and survival of alphabeta T lymphocytes. Nat Immunol 4(6):533-9 |
| abstractText | The gene Bcl11b, which encodes zinc finger proteins, and its paralog, Bcl11a, are associated with immune-system malignancies. We have generated Bcl11b-deficient mice that show a block at the CD4-CD8- double-negative stage of thymocyte development without any impairment in cells of B- or gammadelta T cell lineages. The Bcl11b-/- thymocytes showed unsuccessful recombination of V(beta) to D(beta) and lacked the pre-T cell receptor (TCR) complex on the cell surface, owing to the absence of Tcrb mRNA expression. In addition, we saw profound apoptosis in the thymus of neonatal Bcl11b-/- mice. These results suggest that Bcl11b is a key regulator of both differentiation and survival during thymocyte development. |
