| First Author | Milner LC | Year | 2008 |
| Journal | Genes Brain Behav | Volume | 7 |
| Issue | 4 | Pages | 496-505 |
| PubMed ID | 18182070 | Mgi Jnum | J:149042 |
| Mgi Id | MGI:3847411 | Doi | 10.1111/j.1601-183X.2007.00385.x |
| Citation | Milner LC, et al. (2008) Three murine anxiety models: results from multiple inbred strain comparisons. Genes Brain Behav 7(4):496-505 |
| abstractText | The literature surrounding rodent models of human anxiety disorders is discrepant concerning which models reflect anxiety-like behavior distinct from general activity and whether different models are measuring the same underlying constructs. This experiment compared the responses of 15 inbred mouse strains (129S1/SvlmJ, A/J, AKR/J, BALB/cByJ, C3H/HeJ, C57BL/6J, C57L/J, CBA/J, CE/J, DBA/2J, FVB/NJ, NZB/B1NJ, PL/J, SJL/J and SWR/J) in three anxiety-like behavioral tasks (light/dark test, elevated zero-maze and open field) to examine whether responses were phenotypically and/or genetically correlated across tasks. Significant strain differences were found for all variables examined. Principal components analyses showed that variables associated with both activity and anxiety-like behaviors loaded onto one factor, while urination and defecation loaded onto another factor. Our findings differ from previous research by suggesting that general activity and anxiety-related behaviors are linked, negatively correlated and cannot easily be dissociated in these assays. However, these findings may not necessarily generalize to other unconditioned anxiety-like behavioral tests. |
