| First Author | Okamoto I | Year | 2004 |
| Journal | Science | Volume | 303 |
| Issue | 5658 | Pages | 644-9 |
| PubMed ID | 14671313 | Mgi Jnum | J:93084 |
| Mgi Id | MGI:3055699 | Doi | 10.1126/science.1092727 |
| Citation | Okamoto I, et al. (2004) Epigenetic dynamics of imprinted X inactivation during early mouse development. Science 303(5658):644-9 |
| abstractText | The initiation of X-chromosome inactivation is thought to be tightly correlated with early differentiation events during mouse development. Here, we show that although initially active, the paternal X chromosome undergoes imprinted inactivation from the cleavage stages, well before cellular differentiation. A reversal of the inactive state, with a loss of epigenetic marks such as histone modifications and polycomb proteins, subsequently occurs in cells of the inner cell mass (ICM), which give rise to the embryo-proper in which random X inactivation is known to occur. This reveals the remarkable plasticity of the X-inactivation process during preimplantation development and underlines the importance of the ICM in global reprogramming of epigenetic marks in the early embryo. |
