| First Author | Cha H | Year | 2020 |
| Journal | Front Immunol | Volume | 11 |
| Pages | 1045 | PubMed ID | 32582168 |
| Mgi Jnum | J:324379 | Mgi Id | MGI:6729024 |
| Doi | 10.3389/fimmu.2020.01045 | Citation | Cha H, et al. (2020) Adjustments of gammadelta T Cells in the Lung of Schistosoma japonicum-Infected C56BL/6 Mice. Front Immunol 11:1045 |
| abstractText | Many kinds of lymphocytes are involved in Schistosoma japonicum (S. japonicum) infection-induced disease. gammadelta T cells comprise a small number of innate lymphocytes that quickly respond to foreign materials. In this study, the role of gammadelta T cells in the lung of S. japonicum-infected C56BL/6 mice was investigated. The results demonstrated that S. japonicum infection induces gammadelta T cell accumulation in the lung, expressing higher levels of CD25, MHCII, CD80, and PDL1, and lower levels of CD127 and CD62L (P < 0.05). The intracellular cytokines staining results illustrated higher percentages of IL-4-, IL-10-, IL-21-, and IL-6-producing gammadelta T cells and lower percentages of IFN-gamma-expressing gammadelta T cells in the lung of infected mice (P < 0.05). Moreover, the granuloma size in lung tissue was significantly increased in Vdelta(-/-) mice (P < 0.05). In the lung of S. japonicum-infected Vdelta(-/-) mice, both type 1 and type 2 immune responses were decreased significantly (P < 0.05). In addition, the expression of CD80 and CD69 on B cells was decreased significantly (P < 0.05), and the SEA-specific antibody was markedly decreased (P < 0.05) in the blood of infected Vdelta(-/-) mice. In conclusion, this study indicates that gammadelta T cells could adjust the Th2 dominant immune response in the lung of S. japonicum-infected mice. |
