| First Author | Abtahian F | Year | 2003 |
| Journal | Science | Volume | 299 |
| Issue | 5604 | Pages | 247-51 |
| PubMed ID | 12522250 | Mgi Jnum | J:111210 |
| Mgi Id | MGI:3653293 | Doi | 10.1126/science.1079477 |
| Citation | Abtahian F, et al. (2003) Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. Science 299(5604):247-51 |
| abstractText | Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels, but the molecular signals that regulate this separation are unknown. Here we identify a failure to separate emerging lymphatic vessels from blood vessels in mice lacking the hematopoietic signaling protein SLP-76 or Syk. Blood-lymphatic connections lead to embryonic hemorrhage and arteriovenous shunting. Expression of slp-76 could not be detected in endothelial cells, and blood-filled lymphatics also arose in wild-type mice reconstituted with SLP-76-deficient bone marrow. These studies reveal a hematopoietic signaling pathway required for separation of the two major vascular networks in mammals. |
