| First Author | Thomas DH | Year | 2010 |
| Journal | Blood | Volume | 116 |
| Issue | 14 | Pages | 2570-8 |
| PubMed ID | 20585042 | Mgi Jnum | J:165882 |
| Mgi Id | MGI:4838721 | Doi | 10.1182/blood-2010-02-268136 |
| Citation | Thomas DH, et al. (2010) A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets. Blood 116(14):2570-8 |
| abstractText | T-cell ubiquitin ligand-2 (TULA-2) is a recently discovered histidine tyrosine phosphatase thought to be ubiquitously expressed. In this work, we have investigated whether TULA-2 has a key role in platelet glycoprotein VI (GPVI) signaling. This study indicates that TULA-2 is expressed in human and murine platelets and is able to associate with Syk and dephosphorylate it. Ablation of TULA-2 resulted in hyperphosphorylation of Syk and its downstream effector phospholipase C-gamma2 as well as enhanced GPVI-mediated platelet functional responses. In addition, shorter bleeding times and a prothrombotic phenotype were observed in mice lacking TULA-2. We therefore propose that TULA-2 is the primary tyrosine phosphatase mediating the dephosphorylation of Syk and thus functions as a negative regulator of GPVI signaling in platelets. |
