| Primary Identifier | MGI:109484 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 22631 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Enables protein domain specific binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; synaptic target recognition; and tube morphogenesis. Acts upstream of or within ERK1 and ERK2 cascade; protein targeting; and regulation of programmed cell death. Located in nucleus. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Used to study schizophrenia. Orthologous to human YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta). PHENOTYPE: Mice homozygous for a knock-out allele exhibit growth retardation after P14, some postnatal lethality by P21. Mice homozygous for one gene trap allele also exhibit neurodevelopmental and neuropsychiatric behaviour defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
