| First Author | Pietr M | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 12 | Pages | 2071-6 |
| PubMed ID | 19464294 | Mgi Jnum | J:149991 |
| Mgi Id | MGI:3849516 | Doi | 10.1016/j.febslet.2009.05.028 |
| Citation | Pietr M, et al. (2009) Differential changes in GPR55 during microglial cell activation. FEBS Lett 583(12):2071-6 |
| abstractText | We examined how lipopolysaccharide (LPS) and interferon gamma (IFN-gamma), known to differentially activate microglia, affect the expression of G protein-coupled receptor 55 (GPR55), a novel cannabinoid receptor. We found that GPR55 mRNA is significantly expressed in both primary mouse microglia and the BV-2 mouse microglial cell line, and that LPS down-regulates this message. Conversely, IFN-gamma slightly decreases GPR55 mRNA in primary microglia, while it upregulates this message in BV-2 cells. Moreover, the GPR55 agonist, lysophosphatidylinositol, increases ERK phosphorylation in BV-2 stimulated with IFN-gamma, in correlation with the increased amount of GPR55 mRNA. Remarkably, these stimuli-induced changes in GPR55 expression are similar to those observed with CB(2)-R, suggesting that both receptors might be involved in neuroinflammation and that their expression is concomitantly controlled by the state of microglial activation. |
