Primary Identifier | MGI:3772335 | Allele Type | Targeted |
Attribute String | Humanized sequence, Inserted expressed sequence | Gene | Sgca |
Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
Is Recombinase | false | Is Wild Type | false |
molecularNote | After germline-specific Cre-mediated excision of the floxed neomycin cassette achieved by crossing mice carrying the floxed allele with mice expressing either EIIa-cre or protamine 1-cre, the Sgca locus expresses a transcript bearing the H77C missense mutation. The mutant protein is expressed in the sarcolemma of striated muscles, |