| First Author | Cámara Y | Year | 2011 |
| Journal | Cell Metab | Volume | 13 |
| Issue | 5 | Pages | 527-39 |
| PubMed ID | 21531335 | Mgi Jnum | J:175816 |
| Mgi Id | MGI:5287350 | Doi | 10.1016/j.cmet.2011.04.002 |
| Citation | Camara Y, et al. (2011) MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. Cell Metab 13(5):527-39 |
| abstractText | Precise control of mitochondrial DNA gene expression is critical for regulation of oxidative phosphorylation capacity in mammals. The MTERF protein family plays a key role in this process, and its members have been implicated in regulation of transcription initiation and site-specific transcription termination. We now demonstrate that a member of this family, MTERF4, directly controls mitochondrial ribosomal biogenesis and translation. MTERF4 forms a stoichiometric complex with the ribosomal RNA methyltransferase NSUN4 and is necessary for recruitment of this factor to the large ribosomal subunit. Loss of MTERF4 leads to defective ribosomal assembly and a drastic reduction in translation. Our results thus show that MTERF4 is an important regulator of translation in mammalian mitochondria. |
