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Protein Coding Gene : Rbx1 ring-box 1

Primary Identifier  MGI:1891829 Organism  mouse, laboratory
Chromosome  15 NCBI Gene Number  56438
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable several functions, including cullin family protein binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein ligase activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; cellular response to UV; and protein ubiquitination. Acts upstream of or within protein K48-linked ubiquitination; protein catabolic process; and protein monoubiquitination. Located in cytosol. Part of Cul4A-RING E3 ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including genitourinary system. Orthologous to human RBX1 (ring-box 1).
PHENOTYPE: Mice homozygous for a null mutation display embryonic lethality before somite formation with reduced embryo size and decreased cell proliferation. Embryonic fibroblasts from heterozygous mice display decreased cell proliferation and cell cycle abnormalities. [provided by MGI curators]
  • synonyms:
  • MGI:1913478,
  • Rbx1,
  • 1500002P15Rik,
  • expressed sequence AA517855,
  • ring-box 1,
  • RIKEN cDNA 1500002P15 gene,
  • MGI:2145915,
  • ROC1,
  • AA517855

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

62 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For