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Protein Coding Gene : Mapk1 mitogen-activated protein kinase 1

Primary Identifier  MGI:1346858 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  26413
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and protein serine/threonine kinase activity. Involved in cell surface receptor protein tyrosine kinase signaling pathway; nervous system development; and response to nicotine. Acts upstream of or within several processes, including cell surface receptor signaling pathway; embryonic organ development; and respiratory system development. Located in several cellular components, including cytosol; mitochondrion; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome; autism spectrum disorder; and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 13; Parkinson's disease; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1).
PHENOTYPE: Homozygous mutant embryos implant in the uterus, but die shortly thereafter failing to form extraembryonic tissues. [provided by MGI curators]
  • synonyms:
  • MGI:1921796,
  • AA407128,
  • RIKEN cDNA 9030612K14 gene,
  • MGI:2146551,
  • Mapk1,
  • 9030612K14Rik,
  • expressed sequence C78273,
  • elk related tyrosine kinase 2,
  • mitogen-activated protein kinase 1,
  • MGI:105919,
  • p42mapk,
  • Prkm1,
  • MAPK2,
  • MGD-MRK-33596,
  • MGI:2146700,
  • MGD-MRK-9584,
  • AU018647,
  • C78273,
  • MGI:2146330,
  • protein kinase, mitogen activated kinase 1,
  • expressed sequence AA407128,
  • Erk2,
  • expressed sequence AU018647

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Genome

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1 Involved In Mutations

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

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Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

130 Pathways

1 Targeted By

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Expression

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