| First Author | Li X | Year | 2002 |
| Journal | Science | Volume | 297 |
| Issue | 5584 | Pages | 1180-3 |
| PubMed ID | 12130660 | Mgi Jnum | J:104339 |
| Mgi Id | MGI:3611682 | Doi | 10.1126/science.1073263 |
| Citation | Li X, et al. (2002) Tissue-specific regulation of retinal and pituitary precursor cell proliferation. Science 297(5584):1180-3 |
| abstractText | Mammalian organogenesis requires the expansion of pluripotent precursor cells before the subsequent determination of specific cell types, but the tissue-specific molecular mechanisms that regulate the initial expansion of primordial cells remain poorly defined. We have genetically established that Six6 homeodomain factor, acting as a strong tissue-specific repressor, regulates early progenitor cell proliferation during mammalian retinogenesis and pituitary development. Six6, in association with Dach corepressors, regulates proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. These data reveal a molecular mechanism by which a tissue-specific transcriptional repressor-corepressor complex can provide an organ-specific strategy for physiological expansion of precursor populations. |
