| First Author | Santoro B | Year | 1998 |
| Journal | Cell | Volume | 93 |
| Issue | 5 | Pages | 717-29 |
| PubMed ID | 9630217 | Mgi Jnum | J:47845 |
| Mgi Id | MGI:1266962 | Doi | 10.1016/s0092-8674(00)81434-8 |
| Citation | Santoro B, et al. (1998) Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell 93(5):717-29 |
| abstractText | The generation of pacemaker activity in heart and brain is mediated by hyperpolarization-activated cation channels that are directly regulated by cyclic nucleotides. We previously cloned a novel member of the voltage-gated K channel family from mouse brain (mBCNG-1) that contained a carboxy-terminal cyclic nucleotide-binding domain (Santoro et al., 1997) and hence proposed it to be a candidate gene for pacemaker channels. Heterologous expression of mBCNG-1 demonstrates that it does indeed code for a channel with properties indistinguishable from pacemaker channels in brain and similar to those in heart. Three additional mouse genes and two human genes closely related to mBCNG-1 display unique patterns of mRNA expression in different tissues, including brain and heart, demonstrating that these channels constitute a widely expressed gene family. |
