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Protein Coding Gene : Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif 4

Primary Identifier  MGI:1339949 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  240913
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables metalloendopeptidase activity. Acts upstream of or within defense response to bacterium and proteolysis. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Orthologous to human ADAMTS4 (ADAM metallopeptidase with thrombospondin type 1 motif 4).
PHENOTYPE: Homozygous mutant mice do not exhibit any morphological abnormalities. However, they do display impaired coordination and an increased susceptibility to pharmacologically induced seizures. [provided by MGI curators]
  • synonyms:
  • Adamts4,
  • ADAM metallopeptidase with thrombospondin type 1 motif 4,
  • aggrecanase-1,
  • ADAM-TS4

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

2 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

6 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For