| First Author | Sonnenberg-Riethmacher E | Year | 2007 |
| Journal | Hepatology | Volume | 45 |
| Issue | 2 | Pages | 404-11 |
| PubMed ID | 17256742 | Mgi Jnum | J:121623 |
| Mgi Id | MGI:3710739 | Doi | 10.1002/hep.21461 |
| Citation | Sonnenberg-Riethmacher E, et al. (2007) Maid (GCIP) is involved in cell cycle control of hepatocytes. Hepatology 45(2):404-11 |
| abstractText | The function of Maid (GCIP), a cyclinD-binding helix-loop-helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid-deficient mice-in contrast to wild-type controls--develop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH). Lack of Maid expression after PH was associated with a delay in G1/S-phase progression as evidenced by delayed cyclinA expression and DNA replication in Maid-deficient mice. However, at later time points liver mass was restored normally. Conclusion: These results indicate that Maid is involved in G1/S-phase progression of hepatocytes, which in older animals is associated with the development of liver tumors. |
