| First Author | He Y | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 2 | Pages | 193-9 |
| PubMed ID | 23220088 | Mgi Jnum | J:192555 |
| Mgi Id | MGI:5465371 | Doi | 10.1016/j.febslet.2012.11.024 |
| Citation | He Y, et al. (2013) delta-Catenin overexpression promotes angiogenic potential of CWR22Rv-1 prostate cancer cells via HIF-1alpha and VEGF. FEBS Lett 587(2):193-9 |
| abstractText | This study revealed that CWR22Rv-1 cells overexpressing delta-catenin display bigger tumor formation and higher angiogenic potentials than their matched control cells in the CAM assay. In addition, delta-catenin overexpression in CWR22Rv-1 cells results in increased hypoxia-inducible factor 1-alpha (HIF-1alpha and vascular endothelial growth factor (VEGF) expression. Furthermore, delta-catenin overexpression was found to enhance nuclear distribution of both beta-catenin and HIF-1alpha in hypoxic condition, which is diminished by knockdown of delta-catenin. Our current study adds novel evidence regarding contribution of delta-catenin to the progression of prostate cancer. |
