| First Author | Boggon TJ | Year | 1999 |
| Journal | Science | Volume | 286 |
| Issue | 5447 | Pages | 2119-25 |
| PubMed ID | 10591637 | Mgi Jnum | J:58943 |
| Mgi Id | MGI:1350706 | Doi | 10.1126/science.286.5447.2119 |
| Citation | Boggon TJ, et al. (1999) Implication of tubby proteins as transcription factors by structure-based functional analysis. Science 286(5447):2119-25 |
| abstractText | Tubby-like proteins (TULPs) are found in a broad range of multicellular organisms. In mammals, genetic mutation of tubby or other TULPs can result in one or more of three disease phenotypes: obesity (from which the name 'tubby' is derived), retinal degeneration, and hearing loss. These disease phenotypes indicate a vital role for tubby proteins; however, no biochemical function has yet been ascribed to any member of this protein family. A structure-directed approach was employed to investigate the biological function of these proteins. The crystal structure of the core domain from mouse tubby was determined at a resolution of 1.9 angstroms. From primarily structural clues, experiments were devised, the results of which suggest that TULPs are a unique family of bipartite transcription factors. |
