| Primary Identifier | IPR042132 | Type | Domain |
| Short Name | PX_S6K-delta-1 |
| description | This entry represents the PX domain found in ribosomal protein S6 kinase delta-1. The PX domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions such as cell signaling, vesicular trafficking, protein sorting, and lipid modification, among others [].Ribosomal protein S6 kinase delta-1, also known as RPK118, binds sphingosine kinase-1, a key enzyme in the synthesis of the lipid messenger sphingosine 1 phosphate (SPP). It may be involved in transmitting SPP-mediated signaling into the cell []. RPK118 specifically binds to phosphatidylinositol 3-phosphate []. RPK118 also binds peroxiredoxin-3 and may be involved in transporting peroxiredoxin-3 from the cytoplasm to its mitochondrial site of function via endosome trafficking []. The C terminus of RPK118 consist of a domain with conserved Ser/Thr protein kinase residues, specially resembling human ribosome protein S6 kinase []. |
