| Primary Identifier | MGI:88140 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 12051 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables transcription coactivator activity. Acts upstream of or within several processes, including defense response to other organism; lymphocyte activation involved in immune response; and regulation of gene expression. Predicted to be located in several cellular components, including cytosol; midbody; and nucleoplasm. Predicted to be part of Bcl3-Bcl10 complex and Bcl3/NF-kappaB2 complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; hemolymphoid system; and liver and biliary system. Orthologous to human BCL3 (BCL3 transcription coactivator). PHENOTYPE: Mice lacking functional copies of this gene exhibit defects of the immune system including disruption of the humoral immune response and abnormal spleen and Peyer's patch organogenesis. Mutant mice show increased susceptibility to pathogens. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
