| Primary Identifier | MGI:98258 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 20290 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables cytokine activity. Involved in cellular response to interleukin-17. Acts upstream of or within chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in heart; late tubule; and testis. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; multiple sclerosis; pulmonary tuberculosis; and tuberculosis. Orthologous to human CCL1 (C-C motif chemokine ligand 1). PHENOTYPE: Mice homozygous for a targeted null allele are refractory to the anti-inflammatory response of the statin drug lovastatin and fail to exhibit an increase in regulatory T cell recruitment to sites of inflammation in a model of delayed-type hypersensitivity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
