| Primary Identifier | MGI:98907 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 22262 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables urate oxidase activity. Involved in allantoin metabolic process; amide catabolic process; and purine-containing compound catabolic process. Located in mitochondrion. Is active in peroxisome. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and sensory organ. Used to study hyperuricemia; kidney disease; and nephrogenic diabetes insipidus. Orthologous to human UOX (urate oxidase (pseudogene)). PHENOTYPE: Homozygous null mutants exhibit marked hyperuricemia and urate nephropathy. Most mutants die prior to four weeks of age. Homozygotes for a large paracentric inversion disrupting this same gene exhibit a similar phenotype. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
