| Primary Identifier | MGI:2443999 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 218461 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of or within several processes, including behavioral fear response; learning; and negative regulation of steroid hormone biosynthetic process. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; hindlimb digit; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE8B (phosphodiesterase 8B). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased uring corticosterone, decreased serum adrenocorticotropin and decreased sensitivity to a PDE8-selective inhibitor. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
