| Primary Identifier | IPR014608 | Type | Family |
| Short Name | ATP-citrate_synthase |
| description | This entry represents eukaryotic ATP-citrate synthase (ACLY) (), also known as ATP citrate lyase. In bacteria and archaea, ATP citrate synthase is composed of two distinct subunits []. In eukaryotes, ATP citrate synthase is a homotetramer of a single large polypeptide, and is used to produce cytosolic acetyl-CoA from mitochondrial produced citrate [, , , ]. Acetyl-CoA is the building block for de novo lipid synthesis. As such, ACLY couples energy metabolism with fatty acids synthesis and plays a critical role in supporting cell growth []. |
