| First Author | Costanzo RM | Year | 2008 |
| Journal | Neuroreport | Volume | 19 |
| Issue | 3 | Pages | 327-31 |
| PubMed ID | 18303576 | Mgi Jnum | J:133918 |
| Mgi Id | MGI:3784648 | Doi | 10.1097/WNR.0b013e3282f50c7b |
| Citation | Costanzo RM, et al. (2008) Peak in matrix metaloproteinases-2 levels observed during recovery from olfactory nerve injury. Neuroreport 19(3):327-31 |
| abstractText | Matrix metalloproteineases are associated with extracellular remodeling that occurs in injury and repair processes in the central nervous system (CNS). We examined the role of MMP-2 in a model of olfactory nerve injury and found that MMP-2 levels increased several hours following injury, peaked at day 7 and then decreased rapidly. We previously reported a rapid increase in MMP-9, within 5 h after nerve injury, corresponding to neuronal degeneration and increased glial activity. In this study, we show that MMP-2 peaks later than MMP-9, at the onset of neuronal regeneration and repair. Using MMP-9 knockout mice, we determined that the MMP-2 increase is independent of MMP-9. Our data suggest that MMP-2 and MMP-9 may play different roles in the injury and repair processes. |
