Primary Identifier | MGI:105988 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 13522 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Located in plasma membrane. Is expressed in foregut; nasal cavity epithelium; respiratory system; and thymus. Human ortholog(s) of this gene implicated in breast cancer; estrogen-receptor positive breast cancer; invasive ductal carcinoma; lung adenocarcinoma; and lung non-small cell carcinoma. Orthologous to human ADAM28 (ADAM metallopeptidase domain 28). PHENOTYPE: Homozygous knockout increases metastatic pulmonary colonization after injection with tumor cells as a result of reduced pulmonary CD8+ T cell invasion. [provided by MGI curators] |