| First Author | Lin X | Year | 2021 |
| Journal | iScience | Volume | 24 |
| Issue | 4 | Pages | 102293 |
| PubMed ID | 33723527 | Mgi Jnum | J:304178 |
| Mgi Id | MGI:6694386 | Doi | 10.1016/j.isci.2021.102293 |
| Citation | Lin X, et al. (2021) ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway. iScience 24(4):102293 |
| abstractText | Recently, COVID-19 caused by the novel coronavirus SARS-CoV-2 has brought great challenges to the world. More and more studies have shown that patients with severe COVID-19 may suffer from cytokine storm syndrome; however, there are few studies on its pathogenesis. Here we demonstrated that SARS-CoV-2 coding protein open reading frame 8 (ORF8) acted as a contributing factor to cytokine storm during COVID-19 infection. ORF8 could activate IL-17 signaling pathway and promote the expression of pro-inflammatory factors. Moreover, we demonstrated that treatment of IL17RA antibody protected mice from ORF8-induced inflammation. Our findings are helpful to understand the pathogenesis of cytokine storm caused by SARS-CoV-2 and provide a potential target for the development of COVID-19 therapeutic drugs. |
