| Primary Identifier | IPR002718 | Type | Family |
| Short Name | OMP_Helicobacter |
| description | Gram-negative bacterial outer membranes constitute a semi-permeable, size-dependent permeability barrier, for example to hydrolytic enzymes, detergents, dyes and hydrophobic anti-microbials. The outer membraneprotein (OMP) profile of Helicobacter pylori differs from that of otherGram-negative bacteria, where the highly non-selective porins are absent anda number of less abundant protein species are observed []. OMPs from H. pylori have been identified as porins, gastric epithelial cell adhesins and Lewis Bbinding adhesins []. Extensive C-terminal sequence similarity betweenthese OMPs has been used to define a much larger paralogous family.H. pylori is the causative agent of gastritis and pepticulceration in humans. Numerous subtypes of OMPs have also been identified. Attempts have been made to construct recombinant vectors that are ableto express these OMPs in order to develop a vaccine protecting againstHp infection and a diagnostic reagent kit to quickly detect infection. OMPs were chosen as possible targets of vaccine development as they areH. pylori specific, surface exposed and highly antigenic. |
