| First Author | Sugitani Y | Year | 2002 |
| Journal | Genes Dev | Volume | 16 |
| Issue | 14 | Pages | 1760-5 |
| PubMed ID | 12130536 | Mgi Jnum | J:77999 |
| Mgi Id | MGI:2183078 | Doi | 10.1101/gad.978002 |
| Citation | Sugitani Y, et al. (2002) Brn-1 and Brn-2 share crucial roles in the production and positioning of mouse neocortical neurons. Genes Dev 16(14):1760-5 |
| abstractText | Formation of highly organized neocortical structure depends on the production and correct placement of the appropriate number and types of neurons. POU homeodomain proteins Brn-1 and Brn-2 are coexpressed in the developing neocortex, both in the late precursor cells and in the migrating neurons. Here we show that double disruption of both Brn-1 and Brn-2 genes in mice leads to abnormal formation of the neocortex with dramatically reduced production of layer IV-II neurons and defective migration of neurons unable to express mDab1. These data indicate that Brn-1 and Brn-2 share roles in the production and positioning of neocortical neuron development. |
