| Primary Identifier | IPR027322 | Type | Family |
| Short Name | MAP1S |
| description | MAP1-family proteins are microtubule-associated proteins (MAPs) that bind along the microtubule lattice. Mammalian genomes usually contain three family members, MAP1A, MAP1B and MAP1S. Only one family member, Futsch, is found in Drosophila.Human MAP1S is a heterodimer with a heavy and a light chain. Both MAP1S heavy and light chains interact with microtubules, while MAP1S light chain interacts with actin []. Unlike MAP1A and MAP1B, MAP1S is expressed in a wide range of tissues in addition to neurons []. MAP1S serves as a linker to connect mitochondria with microtubules for trafficking, and to bridge the autophagy machinery with microtubules and mitochondria to affect autophagosomal biogenesis and degradation [, , , ]. In mice, MAP1S may enhance autophagy to suppress genomic instability and tumorigenesis []. |
