| Primary Identifier | MGI:2685198 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 241431 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables alpha-actinin binding activity. Acts upstream of or within cardiac muscle tissue morphogenesis; cell-cell junction organization; and ventricular septum development. Located in Z disc. Is expressed in heart; inner ear; lung; and skeletal muscle. Human ortholog(s) of this gene implicated in depressive disorder. Orthologous to human XIRP2 (xin actin binding repeat containing 2). PHENOTYPE: Homozygous null mice exhibit severe growth retardation, abnormal myocardial fiber morphology, failure of intercalated disc maturation, cardiac conduction and ventricular septal defects, altered ionic currents in cardiomyocytes, and postnatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
