| First Author | Weichenhan D | Year | 1998 |
| Journal | Cytogenet Cell Genet | Volume | 80 |
| Issue | 1-4 | Pages | 226-31 |
| PubMed ID | 9678363 | Mgi Jnum | J:48812 |
| Mgi Id | MGI:1275845 | Doi | 10.1159/000014985 |
| Citation | Weichenhan D, et al. (1998) Evolution by fusion and amplification: the murine Sp100-rs gene cluster. Cytogenet Cell Genet 80(1-4):226-31 |
| abstractText | Sp100 is a single-copy gene in the human and the mouse. A related gene, Sp100-rs, occurs in multiple copies and forms a conspicuous cluster in the mouse chromosome 1. Murine Sp100 and Sp100-rs are homologous from the promoter up to a position in intron 3, but they differ 3' of that position. In the genus Mus, Sp100-rs is present in one phylogenetic branch, represented by the house mouse, M. musculus, but probably does not exist in another branch, represented by M. caroli. Thus, Sp100-rs arose relatively late in the evolution of the genus Mus, whereas Sp100 existed in the common ancestor of the human and the mouse. The Sp100-rs gene cluster probably evolved by gene fusion followed by amplification and diversification. |
