| First Author | Schmidt U | Year | 2009 |
| Journal | Eur J Immunol | Volume | 39 |
| Issue | 11 | Pages | 3228-38 |
| PubMed ID | 19688741 | Mgi Jnum | J:154200 |
| Mgi Id | MGI:4367409 | Doi | 10.1002/eji.200838839 |
| Citation | Schmidt U, et al. (2009) The protein tyrosine kinase Tec regulates mast cell function. Eur J Immunol 39(11):3228-3238 |
| abstractText | Mast cells play crucial roles in a variety of normal and pathophysiological processes and their activation has to be tightly controlled. Here, we demonstrate that the protein tyrosine kinase Tec is a crucial regulator of murine mast cell function. Tec was activated upon FcepsilonRI stimulation of BM-derived mast cells (BMMC). The release of histamine in the absence of Tec was normal in vitro and in vivo; however, leukotriene C(4) levels were reduced in Tec(-) (/) (-) BMMC. Furthermore, the production of IL-4 was severely impaired, and GM-CSF, TNF-alpha and IL-13 levels were also diminished. Finally, a comparison of WT, Tec(-) (/) (-), Btk(-) (/) (-) and Tec(-) (/) (-)Btk(-) (/) (-) BMMC revealed a negative role for Btk in the regulation of IL-4 production, while for the efficient production of TNF-alpha, IL-13 and GM-CSF, both Tec and Btk were required. Our results demonstrate a crucial role for Tec in mast cells, which is partially different to the function of the well-characterized family member Btk. |
