| First Author | Pelkonen J | Year | 1982 |
| Journal | J Immunol | Volume | 129 |
| Issue | 1 | Pages | 242-4 |
| PubMed ID | 6806360 | Mgi Jnum | J:6782 |
| Mgi Id | MGI:55254 | Doi | 10.4049/jimmunol.129.1.242 |
| Citation | Pelkonen J, et al. (1982) Map position of Igh-Oxa gene within the Igh region of the DBA/2 mouse strain. J Immunol 129(1):242-4 |
| abstractText | Mice of 23 BXD recombinant inbred strains derived from the cross of C57BL/6J and DBA/2J were typed for the presence of a public idiotype found in the antibodies against the hapten phenyloxazolone (phOx) produced by DBA/2 mice. The marker is under the control of an immunoglobulin heavy-chain variable region gene, Igh-Ox. Eleven out of the 23 BXK strains shared the public idiotype with the DBA/2 progenitor, while 12 other BXD strains were negative, like the C57BL/6 progenitor. The Igh-Ox marker was inherited concordantly with allotype in all BXD strains except BXD-27, which carries the Igh-1c allotype of DBA/2 but lacks the Igh-Ox idiotype. The Igh-Ox marker was inherited concordantly with 4 other Igh-V markers (Igh-Np, Igh-Nb, Igh-Bgl, and Igh-Gte) in all BXD strains except BXD-20, which has the DBA/2 alleles at Igh-1 and Igh-Ox but resembles C57BL/6 at the other 4 markers. On the basis of these results the Igh-Ox marker is tentatively placed between Igh-C and the rest of the Igh-V markers. |
