| First Author | Fritschy JM | Year | 1998 |
| Journal | Neurosci Lett | Volume | 249 |
| Issue | 2-3 | Pages | 99-102 |
| PubMed ID | 9682826 | Mgi Jnum | J:107941 |
| Mgi Id | MGI:3622576 | Doi | 10.1016/s0304-3940(98)00397-8 |
| Citation | Fritschy JM, et al. (1998) Independent assembly and subcellular targeting of GABA(A)-receptor subtypes demonstrated in mouse hippocampal and olfactory neurons in vivo. Neurosci Lett 249(2-3):99-102 |
| abstractText | The ability of neurons to display more than a single GABA(A)-receptor subtype per cell requires intricate targeting mechanisms. Analysis by confocal laser scanning microscopy revealed that the alpha2- and alpha5-subunits differed strikingly in their subcellular distribution in hippocampal pyramidal cells and olfactory bulb granule cells, while the distribution of the gamma2-subunit was rather uniform. In mutant mice lacking the alpha5-subunit gene due to a chromosomal deletion, the absence of the alpha5-subunit was accompanied by a corresponding decrease of the gamma2-subunit immunoreactivity. In striking contrast, the subcellular distribution of the alpha2-subunit was unchanged in these mutant mice. These findings indicate that the assembly of distinct GABA(A)-receptor subtypes in the same neuron is regulated independently. Furthermore, the alpha-subunit is a prime candidate for providing domains which direct subcellular targeting. |
