| First Author | Izumi-Hisha H | Year | 1990 |
| Journal | Mech Ageing Dev | Volume | 56 |
| Issue | 1 | Pages | 89-97 |
| PubMed ID | 2259257 | Mgi Jnum | J:37383 |
| Mgi Id | MGI:84779 | Doi | 10.1016/0047-6374(90)90117-x |
| Citation | Izumi-Hisha H, et al. (1990) Age-related decrease in the number of hemopoietic stem cells and progenitors in senescence accelerated mice. Mech Ageing Dev 56(1):89-97 |
| abstractText | Senescence accelerated mice (SAM-P) were used for the study of the possible aging of hemopoiesis. The number of peripheral leukocytes decreased significantly with age, whereas hematocrit showed only a slight decrease. Although the number of total nucleated cells in the bone marrow increased, the number of hemopoietic stem cells (CFU-S) as well as that of granulocyte-macrophage colony forming cells (GM-CFC) showed a decrease in old mice. A significant decrease in the number of GM-CFC was observed in the spleen of old SAM-P mice, whereas no decrease was found in the number of CFU-S. Such a profound reduction of the recruitment of GM-CFC from CFU-S in the spleen together with a reduction of bone marrow hemopoiesis may be responsible for the decrease in the number of peripheral leukocytes in the old mice. SAM-P mice could provide a good model for the study of the aging of hemopoietic system. |
